Burroughs fled to Mexico to escape possible detention in Louisiana's Angola state prison. Vollmer and their children followed him. Burroughs planned to stay in Mexico for at least five years, the length of his charge's statute of limitations. Burroughs also attended classes at Mexico City College in 1950 studying Spanish, "Mexican picture writing" (codices) and the Mayan language.

In 1951, Burroughs shot and killed Vollmer in a drunken game of "William Tell" at a party above the American-owned Bounty Bar in Mexico City. He spent 13 days in jail before his brother came to Mexico City and bribed Mexican lawyers and officials, which allowed Burroughs to be released on bail while he awaited trial for the killing, which was ruled culpable homicide.[10] Vollmer’s daughter, Julie Adams, went to live with her grandmother, and William S. Burroughs, Jr. went to St. Louis to live with his grandparents. Burroughs reported every Monday morning to the jail in Mexico City while his prominent Mexican attorney worked to resolve the case. According to James Grauerholz two witnesses had agreed to testify that the gun had gone off accidentally while he was checking to see if it was loaded, and the ballistics experts were bribed to support this story.[11] Nevertheless, the trial was continuously delayed and Burroughs began to write what would eventually become the short novel Queer while awaiting his trial. However, when his attorney fled Mexico after his own legal problems involving a car accident and altercation with the son of a government official, Burroughs decided, according to Ted Morgan, to "skip" and return to the United States. He was convicted in absentia of homicide and sentenced to two years, which was suspended.[12] Although Burroughs was writing before the shooting of Joan Vollmer, this event marked him and, biographers argue, his work for the rest of his life.[13]